Institute worked out:

1. New adsorbents and sorbing technologies.

1.1New technologies of sorption organic substances, oil, acids, metal, including Au, Pt, and Pd Rh, Ir.

1.2New modified adsorbents synthesized on surface of coal, coke, polymeric compositions, also itself polymeric materials.

1.3New technologies for cleaning of production’s gases and water: chemical plants, pipe plants Al-plants at al.

Sorbentes and technological way determine concrete productions and ecological problems. Initial substances for synthesis of sorbentes are remnants of productions. On this basis make new materials with high and electoral sorption. Importance direction of investigation of Institute is:

2. Synthesis of new polymeric materials and modification of production polymers for obtaining better indexes of thermo-, lightstability, and adhesion low cath fire and synthesis biological polymers.

The most success obtained in production:

2.1 Polyvinilchloride (PVC)

2.2 Polymethyl(meth)acrilates

2.3 Polystyrene

2.4 Polyamides

2.5 Polyfluorizated polymers

2.1 PVC has more thermostability that made better ecology of obtaining of PVC-materials and extends application of PVC- materials.

2.2 Polymethyl(meth)acrilates have more thermo-, strike stability. Copolymers with Si-, F-monomers give materials for contact glasses.

2.3 Polystyrene has more strike-stability with using unsaturated and adamantane peroxide Initiators.

2.4 We worked out polyfluorizated polyamides and oligomers on basis e -caprolactam. New polyamides have more thermostability. Polyamide materials have law coefficient of friction and stability in aggressive medium. We obtain compositions on basis new polyamide with more flame resistance.

2.5 Polyfluorizated polymers obtained radical (co)polymerization of polyfluoromonomers and creation of compounds on basis of polyfluorizated polymers for solution of reliable and longeternity of materials working in extreme conditions.

3. Anticorrosive defence of metallic pipes.

3.1 Reorganization of ferroferric oxide and hydrophobization of metallic surface.

We worked out reorganization of ferroferric oxide and hydrophobizaton of metallic surface using higher fatty acides – compounds obtaining by oxidation of hydrocarbons.

3.2 Bituminic-polymeric compositions.

We worked out methods and technology of functionalization bituminic-polymeric materials for better quality of coating of metallic pipes.

3.3 Powdered colours for anticorrosive defence of metallic pipes.

We worked out polyamide coating, PVC coating and compositions on basis polyamides with more reliabe and longeternity in work.

Pharmacologically active amino-acid and pyrimidine base derivatives.

Research in the field of syntesis of amino-acid and pyrimidine base derivatives is being done under suprevision of professor and academcian Alexander Immanuilovich Rakhimov for 15 years in the Institute of Environmental chemical problems of Russian Academy of Science, in the Volgograd State Polytechnical University (chair of Organic Chemistry) and in the Volgograd State Medical Academy (chair of Pharmacology).

The most important result of the research work is that being nontoxic the synthesized compounds reveal:

    1. Anti-virus activity (anti-AIDSvirus activity included),
    2. cardio-vascular effects,
    3. psychotropic activity,
    4. nootropic activity

      5. 1. Anti-virus activity has been revealed in experiments in vitro with DNA and RNA containing viruses: virus of small pox vaccine, virus of simple herpes, virus of Venezuela horse encephalitis, raspirator-cinzitial virus, virus of vesicular stomatitis, virus of classical bird plague, ECHO-6 virus and AIDS-I virus. The most anti herpetic activity of 89 tested compounds has 1-allyloximethy1uracil. This compound has expressed defensive activity on models of mouse herpetic meningoencephalitis and increases survival in animals by 50% and more at low therapeutic doses (0.1 – 1.0 mg/kg) at intrastomach treatment. 1-Allyloximethyluracil at 100 mkg/kg concentration reveals expressed inhibiric activity on herpes virus stamm, resistive to aziklovir activity, and at 30—40- mkg/ml opresses replication of various chiclaen-pox stamms. including defective in timidinkinaze. Citozin and adenine anologues of 1-allyl-oximethyluracil reveal anti AIDS-1 activity in vitro in lymphocytes MI-4. At the same time 1-alliloximetilzitosin can be compared with asidotimidine by selective index but the first one has much lower toxicity.

      2. Cardio-vascular activity of phosphorilic amino-acid derivatives.

      Vascular activity of 62 compounds of phosphorilic amino-acid derivatives of various classes, synthesized by us, has been studied, and among them 16 compounds had expressed hypotensive and hypertensive activity on drugged rats and cats at intravenous injections. All the phosphoritic compound ethers of mediator amino-acids CH3C(O)NH-(CH2)4C(O)O(CH2)3P(O)(OR)2 reveal total correspondence to their cardiovascular activity by non-substituted amino-acids, so glycine derivatives and g -aminobutiric acid cause long-term and considerable decrease of system arterial pressure. At the came time-L-amino-acid derivatives reveal clear pressor effects. L-stereo isomers of 3-dialkoxiphos-phoritic ethers of N-acetylglutamine acid have expressed long-term pressor influence, so with increase of lipofility of glutamine-acid phosphorilic ethers due to the size of alkoxilic groups at phospor attack from methoxi to propoxi the speed of vascular effects development significantly increases. It was found out that pressor effect in case of di (3-dimethoxiphosphorilpropine) ether of glutamine-acid N-acetyl-DL (50 mg/kg) is due to increase of cardiac activity, the minute volume of blood, strike volume and activity of the left ventricle significantly increase. 3-dimethoxiphosphorilpropoxi-2-oxi-propyl ether of N-acetyl-g -aminobutiric acid showed high hypotensive potential in experiments on being awake animals, intravenous injections at 15 mg/kg doses caused decrease of system arterial pressure by 20-22% for 2.5-3.0 hours.

      Study of phosphorilic compound ethers of N-acetyl-L-glutamine acid activity at bulbar stage of blood circulation regulation on the central cardio-vascular mechanism snowed that micro injections of those compounds into rostral and kaudal ventro-lateral zone of oval cerebrum significantly influence both pressor and depressor neuron groups.

      3. Psychotropic activity of phosphorilic deriivatives of neuron active acids. Study of 31 compounds influence at 10-100 mg/kg doses on behavioural activity of rats in the “open field” test showed that reveal of psycho-stimulating and psycho-sedative effects is due to 3 factors; natural basic amino-acid, structure of lipofil phosphor containing fragment and the character of chemical bonds between them. Compound ethers of both stimulating and oppressing amino acids containing dialkoxyphosphorilalkyl substitute in carboxil group show psyhostimulating properties, mostly expressed in dicarbon amino-acid derivatives. Compounds containing glycerine fragment between amino-acid base and phosphorilic alkaholic residuum show contrary tendency. 3-dimethoxiphosphorilpropoxy-2oxy-1 propyl ether of N-acetyl-g -aminobutiric acid having nigh hypotensive activity within 10-100 mg/kg doses shows high psyhostimulating properties, increasing motor activity almost 2 times.

      Di (3-dimethoxilphosphorilpropil) ether of N-acetyl-DL-asparagine acid at 10 mg/kg (1/280 from LD50) dose showed expressed tendency of antiamnestitec action, and at 50 mg/kg (1/55 LD50) dose significantly reconctructed conditional reaction of passive avoidance ruined by electric shock.

      Study of N-acetyl-DL-asparagine-acid lithium salt activity on reserpine depression in cats showed that main peculiar psychotropic action of that compound was its influence on animals’ social behaviour, revealed in total reabilitation of adequate contacts in animal pairs and the leading position in the group without activation of agressive negative type of emotianal behaviour. High antidepressive activity, of N-acetyl-Dl-asparagine acid lithium salt and its optic active analogue with low toxicity (2080 mg/kg intraperitoneal injections in mice) allow as to consider it to be a new drug.

      4.Nootropic activity of phosphoril amino-acids on educational models and tested memory pathology.

      Injections of compounds promoted the forming of place orientation habits in radial labyrinth shortening time for solving behavioural tasks and decreasing mistakes in short and long-term animals’ memory (rats, doses 1 – 50 mg/kg).Nootropic effects were also studied on amnestic models, amnesia caused by scopolamine M cholineblocator and non-competed blocator receptors MK801, that correspond to syndrome of memory ruin at old age.

      N-acetyl-Dl-asparagine acid and its phosphorilic analogue at 50 and 10 mg/kg doses improved reabilitation on amnesia background, caused by scopolamine (3 mg/kg). At acute and long-term treatment nootropic effects appear, abolishing amnesia of different genesis.

    5. New technology of antivirus drug remantadine production has been worked out.
    6. New 6-ethenyl uracil derivatives have been synthesized that are considered to reveal tuberculo static and anti AIDS activity.

We continue our Investigations of synthesis of pyrimidine compounds. At present we obtained anestezine compounded with uracil – substitute.

                                                                                                        

Our anestezine compound has new complex of properties. I will visit USA in June – July. I’d like to visit your firm and to make a lecture about Chemistry of new medical Preparations and to show theirs.